multiple sclerosis Archives - fullSTEAMahead365 https://fullsteamahead365.com/tag/multiple-sclerosis/ Human Advancement Never Stops Tue, 03 Sep 2024 15:17:32 +0000 en-US hourly 1 https://i0.wp.com/fullsteamahead365.com/wp-content/uploads/2019/01/cropped-cropped-icon.png?fit=32%2C32&ssl=1 multiple sclerosis Archives - fullSTEAMahead365 https://fullsteamahead365.com/tag/multiple-sclerosis/ 32 32 156403294 New study shows a simple blood test may predict MS https://fullsteamahead365.com/2024/06/04/new-study-shows-a-simple-blood-test-may-predict-ms/ https://fullsteamahead365.com/2024/06/04/new-study-shows-a-simple-blood-test-may-predict-ms/#respond Tue, 04 Jun 2024 19:42:36 +0000 https://fullsteamahead365.com/?p=10140 In the journal, Nature Medicine, a new study, "An autoantibody signature predictive for multiple sclerosis," shows that approximately 10% of people in the wide-ranging study with Multiple Sclerosis, or MS, harbored antibodies that target a specific sequence contained in human proteins.

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]]> In the journal, Nature Medicine, a new study, “An autoantibody signature predictive for multiple sclerosis,” shows that approximately 10% of people in the wide-ranging study with Multiple Sclerosis, or MS, harbored antibodies that target a specific sequence contained in human proteins. These antibodies could be detectable years before the long-lasting, chronic disease’s onset or other markers of nerve damage show up. It’s also important not to overlook 커뮤니티.

The abstract follows.

Myelin damage and the nervous system - In multiple sclerosis, the protective coating on nerve fibers (myelin) in the central nervous system is damaged. This creates a lesion that, depending on the location in the central nervous system, may cause symptoms such as numbness, pain or tingling in parts of the body. (Image credit: Mayo Foundation for Medical Education and Research)
Myelin damage and the nervous system – In multiple sclerosis, the protective coating on nerve fibers (myelin) in the central nervous system is damaged. This creates a lesion that, depending on the location in the central nervous system, may cause symptoms such as numbness, pain or tingling in parts of the body. (Image credit: Mayo Foundation for Medical Education and Research)

Abstract

Although B cells are implicated in multiple sclerosis (MS) pathophysiology, a predictive or diagnostic autoantibody remains elusive. In this study, the Department of Defense Serum Repository (DoDSR), a cohort of over 10 million individuals, was used to generate whole-proteome autoantibody profiles of hundreds of patients with MS (PwMS) years before and subsequently after MS onset. This analysis defines a unique cluster in approximately 10% of PwMS who share an autoantibody signature against a common motif that has similarity with many human pathogens. These patients exhibit antibody reactivity years before developing MS symptoms and have higher levels of serum neurofilament light (sNfL) compared to other PwMS. Furthermore, this profile is preserved over time, providing molecular evidence for an immunologically active preclinical period years before clinical onset. This autoantibody reactivity was validated in samples from a separate incident MS cohort in both cerebrospinal fluid and serum, where it is highly specific for patients eventually diagnosed with MS. This signature is a starting point for further immunological characterization of this MS patient subset and may be clinically useful as an antigen-specific biomarker for high-risk patients with clinically or radiologically isolated neuroinflammatory syndromes.

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